An extract from an interesting scientific paper.
|Brief history of allergens in vaccines and injections inducing allergy in healthy individuals|
|Nobel Laureate Charles Richet demonstrated over a hundred years ago that injecting proteins into humans or animals causes immune system sensitization to that protein. Subsequent exposure to the same protein can result in anaphylaxis. Let’s call it the Richet allergy model. Wells  demonstrated in 1908 that injecting as little as 50 ng of ovalbumin into guinea pigs resulted in sensitization. Subsequent injections of ovalbumin resulted in an allergic reaction.|
|In 1940, Cooke et al.  describe induction of allergy by a tetanus vaccine. In 1952, Ratner et al.  were concerned about the possibility of sensitization to egg following the administration of influenza vaccines that are manufactured using chicken eggs. They studied a group of 319 subjects and found that 5 of them developed dermal sensitivity to egg following vaccination with vaccines containing egg proteins. All the subjects in the study were undergoing treatment for tuberculosis. The authors probably did not know that tuberculosis infection may offer protection against allergy . They therefore found sensitization in 1.6% of vaccine recipients, even in a population that was protected from allergy, by tuberculosis infection. Yamane et al.  demonstrated a significant increase in anti-ovalbumin IgE in 36 out of 100 subjects following influenza vaccination.|
|San Jose, CA, USA|
|Corresponding Author :||Vinu Arumugham
San Jose, CA, USA